Manuele Gori
EMail0039 3336146384 Orcid Scholar WOS Scopus |
Manuele
Gori
Institute of Biochemistry and Cell Biology Researcher Nutrheff Thematic Biological validation
Research Interest and expertise in the field of nutraceuticals
and functional food
Keywords: Nutraceuticals; Polyphenols; Flavonoids; Hepatic Steatosis; Metabolism; Oxidative Stress; Antioxidants; Anti-inflammatory; Neuroinflammation; Neurodegeneration.
Nutraceuticals and foods of interestCellular and molecular mechanisms underlying the antioxidant, anti-inflammatory and hypolipidemic roles of natural polyphenols (e.g., Quercetin and Hydroxytyrosol) in chronic liver disease [nonalcoholic fatty liver disease (NAFLD)], and Alzheimer's Disease (AD), through in vivo, ex vivo and in vitro approaches leveraging mouse models of AD and alternative in vitro platforms (i.e., liver-on-chip and 3D bioprinted hepatic models) as well as nanoformulated drug delivery systems (i.e., nano-encapsulation of nutraceuticals). Nutraceuticals: Quercetin (polyphenolic flavonoid); Hydroxytyrosol (metabolite of Oleuropein). Foods: apples, grapes, berries, citrus fruits, cherries, broccoli, capers, green tea, coffee, red wine, green olives, extra virgin olive oil. Fields of application Food screening and validation for biological therapies; Dietary supplements; Functional foods and Nutraceuticals market; Food chemistry; 3D Bioprinting and Microfluidics to develop screening platforms for therapeutic food safety and efficacy; Key Enabling Technologies; Preclinical Drug Testing; Healthcare system and welfare programs against chronic liver diseases; Alzheimer's disease; Nanotechnologies. Facilities and equipments BSL-2 cell culture laboratories; chemical laboratory; cold room and hot laboratories; confocal fluorescence microscopy facility: laser scanning confocal and multiphoton microscopes, laser microdissection microscope and TEM; 3D bioprinting laboratory; advanced equipment and supplies for cell culture, biochemistry, molecular biology assays and common areas for neurosurgery, pharmacology and chemistry; UV-VIS Double-beam Spectrophotometer, Sonicator and protein purification systems; Cryostat and Microtome room; DNA sequencer; Real-Time PCR and digital PCR systems; Ultracentrifuge; Multimode microplate reader and flow cytometry facility; in vivo imaging facility: bioluminescence and 3D-OI/CT platform, in-house SSR-SPECT and 3D X-ray Micro-CT systems; European Mouse Mutant Archive (EMMA) and the Infrafrontier-EMMA Monterotondo Mouse Clinic (MMC) international network infrastructures for the life sciences in the context of the International Mouse Phenotyping Consortium (IMPC). |
