Silvia Mandillo
EMail+39-06-90091410 Home Page Orcid Scholar Researchgate WOS Scopus |
Silvia
Mandillo
Institute of Biochemistry and Cell Biology Researcher Nutrheff Thematic Biological validation, Clinical and nutritional studies
Research Interest and expertise in the field of nutraceuticals
and functional food
Keywords: behavioural neuroscience, mouse models, phenotyping, neurodegenerative diseases, neuromuscular diseases, autism, aging
Nutraceuticals and foods of interestWe conduct in-depth behavioural analysis of inbred and mutant mouse models of neurodegenerative and psychiatric diseases in which dietary interventions could ameliorate symptoms or even act as disease-modifying factors. We explore the impact of environmental factors like diet and exercise in these models via the analysis of motor and cognitive functions as well as social and emotional behaviours by using automated systems and ethologically based behavioural observations. anti-oxidants, high fat diet, energy-rich diet Fields of application Psychobiology, Behavioural Pharmacology, Models of Drug Abuse, Neurodegenerative and Psychiatric Diseases, Learning and Memory, Behavioural Neurobiology, Mouse Phenotyping, Animal Welfare, Statistical analysis. Facilities and equipments IBBC is equipped with a state-of-the-art animal house and coordinates the European Mouse Mutant Archive (EMMA) animal facility and the Monterotondo Mouse Clinic (MMC). These research facilities are devoted to the large-scale, standardised production, primary phenotypic analysis, cryopreservation and dissemination of novel murine mutant models of human diseases and their bioinformatic resources. Molecular Facility - Tissue culture room: fully equipped for basic research in biochemistry, molecular and cell biology. Behavioural Neurobiology Facility - equipped for in-depth behavioural analysis of mouse models of neurological and neuropsychiatric diseases for the study of motor and cognitive functions, social and emotional behaviours by using automated systems and ethologically based direct observations. Also available an advanced system of mouse home cage monitoring (DVC) for the measure of physiological and behavioural parameters, long-term and non-invasively. |
